Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.
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ABSTRACT:
SUBMITTER: Turkington HL
PROVIDER: S-EPMC4580192 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.
Turkington Hannah L HL Juozapaitis Mindaugas M Kerry Philip S PS Aydillo Teresa T Ayllon Juan J García-Sastre Adolfo A Schwemmle Martin M Hale Benjamin G BG
Journal of virology 20150805 20
We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon antagonists but do not block general host gene expression. Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical homodimer, and RNA binding required conserved basic residues in this domain. Interferon antagonism was strictly dependent on RNA binding, and chimeric bat influenza viruses expressing NS1s defective in this activity were highly attenuated in interferon-c ...[more]
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