A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.
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ABSTRACT:
SUBMITTER: Chan YK
PROVIDER: S-EPMC4837045 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.
Chan Ying Kai YK Gack Michaela U MU
Nature immunology 20160321 5
14-3-3 proteins regulate biological processes by binding to phosphorylated serine or phosphorylated threonine motifs of cellular proteins. Among the 14-3-3 proteins, 14-3-3ɛ serves a crucial function in antiviral immunity by mediating the cytosol-to-mitochondrial membrane translocation of the pathogen sensor RIG-I. Here we found that the NS3 protein of dengue virus (DV) bound to 14-3-3ɛ and prevented translocation of RIG-I to the adaptor MAVS and thereby blocked antiviral signaling. Intriguingly ...[more]
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