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Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives.

ABSTRACT: In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tanshinones might be potential candidates as antibacterial agents.

SUBMITTER: Wang D 

PROVIDER: S-EPMC4581214 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives.

Wang Dongdong D   Zhang Wuxia W   Wang Tingting T   Li Na N   Mu Haibo H   Zhang Jiwen J   Duan Jinyou J  

International journal of molecular sciences 20150731 8

In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tansh  ...[more]

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