Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives.
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ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC4581214 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
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Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives.
Wang Dongdong D Zhang Wuxia W Wang Tingting T Li Na N Mu Haibo H Zhang Jiwen J Duan Jinyou J
International journal of molecular sciences 20150731 8
In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tansh ...[more]
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