Antibacterial Activity and Mode of Action of Lactoquinomycin A from Streptomyces bacillaris.

ABSTRACT: This study aims to isolate and identify the structure of antibacterial compounds having potent activity on methicillin-resistant Staphylococcus aureus (MRSA) from marine actinomycetes, and also to identify their mode of action. Lactoquinomycin A (LQM-A) (compound 1) and its derivatives (2-4) were isolated from marine-derived Streptomyces bacillaris strain MBTC38, and their structures were determined using extensive spectroscopic methods. These compounds showed potent antibacterial activities against Gram-positive bacteria, with MIC values of 0.06-4 μg/mL. However, the tested compounds exhibited weak inhibitory activity against Gram-negative bacteria, although they were effective against Salmonella enterica (MIC = 0.03-1 μg/mL). LQM-A exhibited the

SUBMITTER: Chung B 

PROVIDER: S-EPMC7823745 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature