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Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.

ABSTRACT: Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

SUBMITTER: Wang J

PROVIDER: S-EPMC4581331 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Regulatory Roles of Non-Coding RNAs in Colorectal Cancer.

Wang Jun J Song Yong-Xi YX Ma Bin B Wang Jia-Jun JJ Sun Jing-Xu JX Chen Xiao-Wan XW Zhao Jun-Hua JH Yang Yu-Chong YC Wang Zhen-Ning ZN

International journal of molecular sciences 20150821 8

Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs ...[more]

PMID: 26307974

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