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Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.

ABSTRACT: The mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory interneurons, generated in dorsal and ventral progenitor zones of the embryonic telencephalon, respectively. Thus, inhibitory neurons migrate relatively long distances to reach their destination in the developing forebrain. The role of lineage in the organization and circuitry of interneurons is still not well understood. Utilizing a combination of genetics, retroviral fate mapping, and lineage-specific retroviral barcode labeling, we find that clonally related interneurons can be widely dispersed while unrelated interneurons can be closely clustered. These data suggest that migratory mechanisms related to the clustering of interneurons occur largely independent of their clonal origin.

SUBMITTER: Harwell CC

PROVIDER: S-EPMC4581718 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.

Harwell Corey C CC Fuentealba Luis C LC Gonzalez-Cerrillo Adrian A Parker Phillip R L PR Gertz Caitlyn C CC Mazzola Emanuele E Garcia Miguel Turrero MT Alvarez-Buylla Arturo A Cepko Constance L CL Kriegstein Arnold R AR

Neuron 20150820 5

The mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory interneurons, generated in dorsal and ventral progenitor zones of the embryonic telencephalon, respectively. Thus, inhibitory neurons migrate relatively long distances to reach their destination in the developing forebrain. The role of lineage in the organization and circuitry of interneurons is still not well understood. Utilizing a combination of genetics, ret ...[more]

PMID: 26299474

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