MIND diet slows cognitive decline with aging.
Ontology highlight
ABSTRACT:
SUBMITTER: Morris MC
PROVIDER: S-EPMC4581900 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
MIND diet slows cognitive decline with aging.
Morris Martha Clare MC Tangney Christy C CC Wang Yamin Y Sacks Frank M FM Barnes Lisa L LL Bennett David A DA Aggarwal Neelum T NT
Alzheimer's & dementia : the journal of the Alzheimer's Association 20150615 9
<h4>Introduction</h4>The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention.<h4>Methods</h4>We devised the Mediterranean-Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants ...[more]
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Project description:Recent microarray studies in the hippocampus of rodents or Alzheimerâs disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. These were correlated with performance scores on the hippocampus-dependent Morris Water Maze task. 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