Ontology highlight
ABSTRACT:
SUBMITTER: Weghofer M
PROVIDER: S-EPMC4582595 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Weghofer Margit M Grote Monika M Resch Yvonne Y Casset Anne A Kneidinger Michael M Kopec Jolanta J Thomas Wayne R WR Fernández-Caldas Enrique E Kabesch Michael M Ferrara Rosetta R Mari Adriano A Purohit Ashok A Pauli Gabrielle G Horak Friedrich F Keller Walter W Valent Peter P Valenta Rudolf R Vrtala Susanne S
Journal of immunology (Baltimore, Md. : 1950) 20130304 7
The house dust mite (HDM) Dermatophagoides pteronyssinus is one of most important allergen sources and a major elicitor of allergic asthma. We screened a D. pteronyssinus expression cDNA library with IgE Abs from HDM allergic patients. A cDNA coding for a new major allergen was isolated, which showed sequence homology to peritrophins, which contain chitin-binding domains and are part of the peritrophic matrix lining the gut of arthropods. The mature Der p 23 allergen was expressed in Escherichia ...[more]