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B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.

ABSTRACT: The protective role of B cells and humoral immune responses in tuberculosis infection has been regarded as inferior to cellular immunity directed to the intracellular pathogen Mycobacterium tuberculosis. However, B-cell-mediated immune responses in tuberculosis have recently been revisited in the context of B-cell physiology and antigen presentation. We discuss in this review the diverse functions of B cells in tuberculosis, with a focus on their biological and clinical relevance to progression of active disease. We also present the peptide microarray platform as a promising strategy to discover unknown antigenic targets of M. tuberculosis that could contribute to the better understanding of epitope focus of the humoral immune system against M. tuberculosis.

SUBMITTER: Rao M

PROVIDER: S-EPMC4583574 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.

Rao Martin M Valentini Davide D Poiret Thomas T Dodoo Ernest E Parida Shreemanta S Zumla Alimuddin A Brighenti Susanna S Maeurer Markus M

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20151001

The protective role of B cells and humoral immune responses in tuberculosis infection has been regarded as inferior to cellular immunity directed to the intracellular pathogen Mycobacterium tuberculosis. However, B-cell-mediated immune responses in tuberculosis have recently been revisited in the context of B-cell physiology and antigen presentation. We discuss in this review the diverse functions of B cells in tuberculosis, with a focus on their biological and clinical relevance to progression ...[more]

PMID: 26409285

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