Ontology highlight
ABSTRACT:
SUBMITTER: Oti M
PROVIDER: S-EPMC4584025 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Oti Martin M Kouwenhoven Evelyn N EN Zhou Huiqing H
Genomics data 20150609
The transcription factor p63 is a key regulator in epidermal keratinocyte proliferation and differentiation. However, the role of p63 in gene regulation during these processes is not well understood. To investigate this, we recently generated genome-wide profiles of gene expression, p63 binding sites and active regulatory regions with the H3K27ac histone mark (Kouwenhoven et al., 2015). We showed that only a subset of p63 binding sites are active in keratinocytes, and that differentiation-associ ...[more]