Ontology highlight
ABSTRACT:
SUBMITTER: Hamanaka RB
PROVIDER: S-EPMC5441935 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Hamanaka Robert B RB Mutlu Gökhan M GM
The Journal of investigative dermatology 20170117 6
p63 is a transcription factor essential for epidermal development and homeostasis. p63 is a member of the p53 family of transcription factors, which are increasingly understood to be regulators of cellular metabolism. How p63 regulates metabolism in epidermal keratinocytes is incompletely understood, and it is unknown whether glycolytic regulation is essential to maintain the balance between proliferation and differentiation within the epidermis. We found that p63 promotes glycolytic metabolism ...[more]