Ontology highlight
ABSTRACT:
SUBMITTER: Schwartz BD
PROVIDER: S-EPMC4584354 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Marine drugs 20150915 9
Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds present in the thiaplakortones. All compounds were fully characterized using NMR and MS data. A single crystal X-ray structure was obtained on one of the N-tosyl derivatives. All compound ...[more]