Dataset Information

Multifunctional Supramolecular Hybrid Materials Constructed from Hierarchical Self-Ordering of In Situ Generated Metal-Organic Framework (MOF) Nanoparticles.

ABSTRACT: A synergistic approach is described to engineer supramolecular hybrid materials based on metal-organic frameworks, encompassing HKUST-1 nanoparticles formed in situ, coexisting with an electrically conducting gel fiber network. The following findings are made: i) multistimuli-responsive structural transformation via reversible sol-gel switching and ii) radical conversion of a soft hybrid gel into a mechanically malleable, viscoelastic matter.

SUBMITTER: Chaudhari AK

PROVIDER: S-EPMC4584506 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Multifunctional Supramolecular Hybrid Materials Constructed from Hierarchical Self-Ordering of In Situ Generated Metal-Organic Framework (MOF) Nanoparticles.

Chaudhari Abhijeet K AK Han Intaek I Tan Jin-Chong JC

Advanced materials (Deerfield Beach, Fla.) 20150625 30

A synergistic approach is described to engineer supramolecular hybrid materials based on metal-organic frameworks, encompassing HKUST-1 nanoparticles formed in situ, coexisting with an electrically conducting gel fiber network. The following findings are made: i) multistimuli-responsive structural transformation via reversible sol-gel switching and ii) radical conversion of a soft hybrid gel into a mechanically malleable, viscoelastic matter. ...[more]

PMID: 26115476

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Project description:The development of molecular biology has led to the identification of protein-based therapeutics as an intriguing approach for the treatment of a wide range of diseases. To manufacture transcellular protein delivery shuttles, we attempted charge reversal chemistry on native proteins [e.g., superoxide dismutase (SOD): an enzyme capable of scavenging detrimental reactive oxygen species] by the selective conversion of the positively charged amino residues of native SOD to conjugated negatively charged citraconic moieties, eliciting overall negatively charged polyelectrolytes for the subsequent electrostatic self-assembly with cationic metal-organic framework (MOF) derivatives into protein delivery systems. Please note that the charge conversion was reversible, restoring the original amino groups in intracellular acidic endosome compartments (pH 5), which afforded facile charge reversible functions to reclaim the active SOD in the cell interior. In particular, the strategic manufacture of dendritic MOF supramolecular architectures as transcellular shuttles for the aforementioned charge-reversible SOD derivatives is noteworthy. The MOF was surface-functionalized with several polycationic segments, thus contributing to the hyper-charged architecture for the easy accommodation of the negatively charged SOD derivatives. Consequently, the SOD derivatives managed to internalize into cells by hitchhiking via endocytosis of the positively charged MOF. Once they resided in the acidic endosomes, the charge reversal of the SOD derivatives could occur smoothly and result in reduced interactions between the charged-reversed SOD and MOF, leading to the release of active SOD. Simultaneously, the dendritic MOF due to protein release presented a highly positive-charged architecture to provoke endosome membrane disruption, consequently spurring the translocation of SOD to the cytosol for the execution of its enzymatic activities. Herein, the intracellular ROS level of the activated macrophages was validated to be markedly suppressed by our proposed transcellular SOD shuttles, thereby indicating their wide availability to diverse functional proteins for biomedical applications.

Dataset Information

Multifunctional Supramolecular Hybrid Materials Constructed from Hierarchical Self-Ordering of In Situ Generated Metal-Organic Framework (MOF) Nanoparticles.

Publications

Multifunctional Supramolecular Hybrid Materials Constructed from Hierarchical Self-Ordering of In Situ Generated Metal-Organic Framework (MOF) Nanoparticles.

Similar Datasets

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