Ontology highlight
ABSTRACT:
SUBMITTER: Heng YH
PROVIDER: S-EPMC4585514 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Heng Yee Hsieh Evelyn YH Zhou Bo B Harris Lachlan L Harvey Tracey T Smith Aaron A Horne Elise E Martynoga Ben B Andersen Jimena J Achimastou Angeliki A Cato Kathleen K Richards Linda J LJ Gronostajski Richard M RM Yeo Giles S GS Guillemot François F Bailey Timothy L TL Piper Michael M
Cerebral cortex (New York, N.Y. : 1991) 20141019 10
Transcription factors of the nuclear factor one (NFI) family play a pivotal role in the development of the nervous system. One member, NFIX, regulates the development of the neocortex, hippocampus, and cerebellum. Postnatal Nfix(-/-) mice also display abnormalities within the subventricular zone (SVZ) lining the lateral ventricles, a region of the brain comprising a neurogenic niche that provides ongoing neurogenesis throughout life. Specifically, Nfix(-/-) mice exhibit more PAX6-expressing prog ...[more]