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Infection with Streptococcus pneumoniae triggers progression of pulmonary fibrosis by pneumolysin

ABSTRACT: A two-hit model of adenoviral vector delivery of active transforming growth factor-β (TGFb) 1 to induce fibrosis in mice in conjunction with treatment of the mice with purified pneumolysin from Streptococcus pneumoniae was applied to characterize the role of this virulence factor on fibrosis perpetuation in mice The study was supported by a BMBF grant for the German Center for Lung Research, partner site BREATH (Biomedical Research in Endstage and Obstructive Lung Disease Hannover)

ORGANISM(S): Mus musculus

PROVIDER: GSE52890 | GEO | 2017/09/01

SECONDARY ACCESSION(S): PRJNA230400

REPOSITORIES: GEO

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