Ontology highlight
ABSTRACT:
SUBMITTER: Pellett S
PROVIDER: S-EPMC4585966 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Pellett Sabine S Schwartz Michael P MP Tepp William H WH Josephson Richard R Scherf Jacob M JM Pier Christina L CL Thomson James A JA Murphy William L WL Johnson Eric A EA
Scientific reports 20150928
Botulinum neurotoxin (BoNT) detection provides a useful model for validating cell-based neurotoxicity screening approaches, as sensitivity is dependent on functionally competent neurons and clear quantitative endpoints are available for correlating results to approved animal testing protocols. Here, human induced pluripotent stem cell (iPSC)-derived neuronal cells were cultured on chemically-defined poly(ethylene glycol) (PEG) hydrogels formed by "thiol-ene" photopolymerization and tested as a c ...[more]