Ontology highlight
ABSTRACT:
SUBMITTER: Inaba M
PROVIDER: S-EPMC4586072 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Inaba Mayu M Buszczak Michael M Yamashita Yukiko M YM
Nature 20150701 7560
Stem cell niches provide resident stem cells with signals that specify their identity. Niche signals act over a short range such that only stem cells but not their differentiating progeny receive the self-renewing signals. However, the cellular mechanisms that limit niche signalling to stem cells remain poorly understood. Here we show that the Drosophila male germline stem cells form previously unrecognized structures, microtubule-based nanotubes, which extend into the hub, a major niche compone ...[more]