Ontology highlight
ABSTRACT:
SUBMITTER: Ozcan L
PROVIDER: S-EPMC4587644 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Ozcan Lale L Xu Xiaoming X Deng Shi-Xian SX Ghorpade Devram S DS Thomas Tiffany T Cremers Serge S Hubbard Brian B Serrano-Wu Michael H MH Gaestel Matthias M Landry Donald W DW Tabas Ira I
Diabetes 20150611 10
The prevalence of obesity-induced type 2 diabetes (T2D) is increasing worldwide, and new treatment strategies are needed. We recently discovered that obesity activates a previously unknown pathway that promotes both excessive hepatic glucose production (HGP) and defective insulin signaling in hepatocytes, leading to exacerbation of hyperglycemia and insulin resistance in obesity. At the hub of this new pathway is a kinase cascade involving calcium/calmodulin-dependent protein kinase II (CaMKII), ...[more]