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Central IGF1 improves glucose tolerance and insulin sensitivity in mice.

ABSTRACT: Insulin-like growth factor 1 (IGF1) is a key factor for tissue growth and fuel metabolism. The potential function of central IGF1 remains unclear. We previously observed that IGF1 expression is increased in the hypothalamus of obese mice lacking STAT5 in the central nervous system (CNS). In this study, we explored the potential metabolic function of central IGF1 by intracerebroventricular (ICV) injection of IGF1, over-expression of central IGF1 by administering an adeno-associated virus (AAV), and ICV injection of an anti-IGF1 antibody. Mice that over-expressed central IGF1 displayed increased appetite, improved glucose tolerance and insulin sensitivity, decreased Pomc levels in the hypothalamus, and increased UCP1 expression in brown fat tissue. This is the first study demonstrating that central IGF1 regulates several important metabolic functions.

SUBMITTER: Hong H

PROVIDER: S-EPMC5865549 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Central IGF1 improves glucose tolerance and insulin sensitivity in mice.

Hong Hao H Cui Zhen-Zhong ZZ Zhu Lu L Fu Shu-Ping SP Rossi Mario M Cui Ying-Hong YH Zhu Bing-Mei BM

Nutrition & diabetes 20171219 12

Insulin-like growth factor 1 (IGF1) is a key factor for tissue growth and fuel metabolism. The potential function of central IGF1 remains unclear. We previously observed that IGF1 expression is increased in the hypothalamus of obese mice lacking STAT5 in the central nervous system (CNS). In this study, we explored the potential metabolic function of central IGF1 by intracerebroventricular (ICV) injection of IGF1, over-expression of central IGF1 by administering an adeno-associated virus (AAV), a ...[more]

PMID: 29259155

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