Ontology highlight
ABSTRACT:
SUBMITTER: Richer MJ
PROVIDER: S-EPMC4588296 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Richer Martin J MJ Pewe Lecia L LL Hancox Lisa S LS Hartwig Stacey M SM Varga Steven M SM Harty John T JT
The Journal of clinical investigation 20150804 9
Due to their ability to rapidly proliferate and produce effector cytokines, memory CD8+ T cells increase protection following reexposure to a pathogen. However, low inflammatory immunizations do not provide memory CD8+ T cells with a proliferation advantage over naive CD8+ T cells, suggesting that cell-extrinsic factors enhance memory CD8+ T cell proliferation in vivo. Herein, we demonstrate that inflammatory signals are critical for the rapid proliferation of memory CD8+ T cells following infec ...[more]