Ontology highlight
ABSTRACT:
SUBMITTER: Adachi T
PROVIDER: S-EPMC4636445 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Adachi Takeya T Kobayashi Tetsuro T Sugihara Eiji E Yamada Taketo T Ikuta Koichi K Pittaluga Stefania S Saya Hideyuki H Amagai Masayuki M Nagao Keisuke K
Nature medicine 20151019 11
The skin harbors a variety of resident leukocyte subsets that must be tightly regulated to maintain immune homeostasis. Hair follicles are unique structures in the skin that contribute to skin dendritic cell homeostasis through chemokine production. We demonstrate that CD4(+) and CD8(+) skin-resident memory T cells (TRM cells), which are responsible for long-term skin immunity, reside predominantly within the hair follicle epithelium of the unperturbed epidermis. TRM cell tropism for the epiderm ...[more]