Factoring the brain signatures of anesthesia concentration and level of arousal across individuals.
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ABSTRACT:
SUBMITTER: Barttfeld P
PROVIDER: S-EPMC4588413 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Factoring the brain signatures of anesthesia concentration and level of arousal across individuals.
Barttfeld Pablo P Bekinschtein Tristan A TA Salles Alejo A Stamatakis Emmanuel A EA Adapa Ram R Menon David K DK Sigman Mariano M
NeuroImage. Clinical 20150903
Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disco ...[more]
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