Ontology highlight
ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC10517397 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Guo Yongxin Y Song Yanping Y Cao Fuyang F Li Ao A Hao Xinyu X Shi Wenzhu W Zhou Zhikang Z Cao Jiangbei J Liu Yanhong Y Mi Weidong W Tong Li L
iScience 20230814 9
The mechanism of general anesthesia remains elusive. The ventrolateral periaqueductal gray (vlPAG) in the midbrain regulates sleep and awake states. However, the role of vlPAG and its circuits in anesthesia is unclear. We utilized opto/chemogenetics, righting reflex, and electroencephalographic recording to assess consciousness changes. We employed fiber photometry to measure the activity of neurons and neurotransmitters. As a result, photometry recording showed that the activity of GABA neurons ...[more]