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Quantifying barcodes of dendritic spines using entropy-based metrics.


ABSTRACT: Spine motility analysis has become the mainstay for investigating synaptic plasticity but is limited in its versatility requiring complex, non automatized instrumentations. We describe an entropy-based method for determining the spatial distribution of dendritic spines that allows successful estimation of spine motility from still images. This method has the potential to extend the applicability of spine motility analysis to ex vivo preparations.

SUBMITTER: Viggiano D 

PROVIDER: S-EPMC4588562 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Quantifying barcodes of dendritic spines using entropy-based metrics.

Viggiano D D   Srivastava D P DP   Speranza L L   Perrone-Capano C C   Bellenchi G C GC   di Porzio U U   Buckley N J NJ  

Scientific reports 20150930


Spine motility analysis has become the mainstay for investigating synaptic plasticity but is limited in its versatility requiring complex, non automatized instrumentations. We describe an entropy-based method for determining the spatial distribution of dendritic spines that allows successful estimation of spine motility from still images. This method has the potential to extend the applicability of spine motility analysis to ex vivo preparations. ...[more]

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