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Organization of TNIK in dendritic spines.

ABSTRACT: Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high-resolution light and electron microscopic immunocytochemistry. We demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain. In striatum and cerebral cortex, TNIK concentrates in dendritic spines, especially in the vicinity of the lateral edge of the synapse. Thus, TNIK is highly enriched at a microdomain critical for glutamatergic signaling.

SUBMITTER: Burette AC

PROVIDER: S-EPMC4509985 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Organization of TNIK in dendritic spines.

Burette Alain C AC Phend Kristen D KD Burette Susan S Lin Qingcong Q Liang Musen M Foltz Gretchen G Taylor Noël N Wang Qi Q Brandon Nicholas J NJ Bates Brian B Ehlers Michael D MD Weinberg Richard J RJ

The Journal of comparative neurology 20150701 13

Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high-resolution light and electron microscopic immunocytochemistry. We demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain. In striatum and cerebral cortex, ...[more]

PMID: 25753355

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