Unknown

Dataset Information

0

Organization of TNIK in dendritic spines.


ABSTRACT: Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high-resolution light and electron microscopic immunocytochemistry. We demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain. In striatum and cerebral cortex, TNIK concentrates in dendritic spines, especially in the vicinity of the lateral edge of the synapse. Thus, TNIK is highly enriched at a microdomain critical for glutamatergic signaling.

SUBMITTER: Burette AC 

PROVIDER: S-EPMC4509985 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications


Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high-resolution light and electron microscopic immunocytochemistry. We demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain. In striatum and cerebral cortex,  ...[more]

Similar Datasets

| S-EPMC6705222 | biostudies-literature
| S-EPMC11369513 | biostudies-literature
| S-EPMC11296318 | biostudies-literature
| S-EPMC4471661 | biostudies-other
| S-EPMC2800307 | biostudies-literature
| S-EPMC3752161 | biostudies-literature
| S-EPMC5709047 | biostudies-literature
| S-EPMC4286724 | biostudies-literature
| S-EPMC6802951 | biostudies-literature
| S-EPMC3410382 | biostudies-other