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Infants born large-for-gestational-age display slower growth in early infancy, but no epigenetic changes at birth.

ABSTRACT: We evaluated the growth patterns of infants born large-for-gestational-age (LGA) from birth to age 1 year compared to those born appropriate-for-gestational-age (AGA). In addition, we investigated possible epigenetic changes associated with being born LGA. Seventy-one newborns were classified by birth weight as AGA (10(th)-90(th) percentile; n?=?42) or LGA (>90(th) percentile; n?=?29). Post-natal follow-up until age 1 year was performed with clinical assessments at 3, 6, and 12 months. Genome-wide DNA methylation was analysed on umbilical tissue in 19 AGA and 27 LGA infants. At birth, LGA infants had greater weight (p?

SUBMITTER: Chiavaroli V 

PROVIDER: S-EPMC4588582 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Infants born large-for-gestational-age display slower growth in early infancy, but no epigenetic changes at birth.

Chiavaroli Valentina V   Cutfield Wayne S WS   Derraik José G B JG   Pan Zengxiang Z   Ngo Sherry S   Sheppard Allan A   Craigie Susan S   Stone Peter P   Sadler Lynn L   Ahlsson Fredrik F  

Scientific reports 20150930

We evaluated the growth patterns of infants born large-for-gestational-age (LGA) from birth to age 1 year compared to those born appropriate-for-gestational-age (AGA). In addition, we investigated possible epigenetic changes associated with being born LGA. Seventy-one newborns were classified by birth weight as AGA (10(th)-90(th) percentile; n = 42) or LGA (>90(th) percentile; n = 29). Post-natal follow-up until age 1 year was performed with clinical assessments at 3, 6, and 12 months. Genome-wi  ...[more]

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