Ontology highlight
ABSTRACT:
SUBMITTER: Kleiner RE
PROVIDER: S-EPMC4589150 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nature chemical biology 20150907 10
DNA double-strand break repair involves phosphorylation of histone variant H2AX ('γH2AX'), which accumulates in foci at sites of DNA damage. In current models, the recruitment of multiple DNA repair proteins to γH2AX foci depends mainly on recognition of this 'mark' by a single protein, MDC1. However, DNA repair proteins accumulate at γH2AX sites without MDC1, suggesting that other 'readers' of this mark exist. Here, we use a quantitative chemical proteomics approach to profile direct, phospho-s ...[more]