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Proteomics reveals a new DNA repair factor involved in DNA damage signaling.

ABSTRACT: Stalling of the DNA replication machinery activates the ATR checkpoint kinase, which coordinates the cellular responses to replication stress. New studies identify a novel ATR activator, ETAA1, which is indispensable for the maintenance of genome integrity. Dysregulation of ETAA1 may contribute to the development of pancreatic cancer.

SUBMITTER: Raschle M

PROVIDER: S-EPMC5287004 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Proteomics reveals a new DNA repair factor involved in DNA damage signaling.

Räschle Markus M

Molecular & cellular oncology 20161129 1

Stalling of the DNA replication machinery activates the ATR checkpoint kinase, which coordinates the cellular responses to replication stress. New studies identify a novel ATR activator, ETAA1, which is indispensable for the maintenance of genome integrity. Dysregulation of ETAA1 may contribute to the development of pancreatic cancer. ...[more]

PMID: 28197536

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