Ontology highlight
ABSTRACT:
SUBMITTER: Barbier-Torres L
PROVIDER: S-EPMC4589448 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Barbier-Torres Lucía L Beraza Naiara N Fernández-Tussy Pablo P Lopitz-Otsoa Fernando F Fernández-Ramos David D Zubiete-Franco Imanol I Varela-Rey Marta M Delgado Teresa C TC Gutiérrez Virginia V Anguita Juan J Pares Albert A Banales Jesús M JM Villa Erica E Caballería Juan J Alvarez Luis L Lu Shelly C SC Mato Jose M JM Martínez-Chantar María Luz ML
Hepatology (Baltimore, Md.) 20150731 4
<h4>Unlabelled</h4>Prohibitin-1 (PHB1) is an evolutionarily conserved pleiotropic protein that participates in diverse processes depending on its subcellular localization and interactome. Recent data have indicated a diverse role for PHB1 in the pathogenesis of obesity, cancer, and inflammatory bowel disease, among others. Data presented here suggest that PHB1 is also linked to cholestatic liver disease. Expression of PHB1 is markedly reduced in patients with primary biliary cirrhosis and biliar ...[more]