Ontology highlight
ABSTRACT:
SUBMITTER: Lohmann F
PROVIDER: S-EPMC4589598 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Lohmann Felix F Dangeti Mohan M Soni Shefali S Chen Xiaoyong X Planutis Antanas A Baron Margaret H MH Choi Kyunghee K Bieker James J JJ
Molecular and cellular biology 20150824 21
Understanding how transcriptional regulators are themselves controlled is important in attaining a complete picture of the intracellular effects that follow signaling cascades during early development and cell-restricted differentiation. We have addressed this issue by focusing on the regulation of EKLF/KLF1, a zinc finger transcription factor that plays a necessary role in the global regulation of erythroid gene expression. Using biochemical affinity purification, we have identified the DEK onc ...[more]