NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor.
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ABSTRACT:
SUBMITTER: Schmidt J
PROVIDER: S-EPMC4589779 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor.
Schmidt Jurema J Klingler Franca-Maria FM Proschak Ewgenji E Steinhilber Dieter D Schubert-Zsilavecz Manfred M Merk Daniel D
Scientific reports 20151001
The nuclear farnesoid X receptor (FXR) is a ligand activated transcription factor and acts as cellular sensor for bile acids. In this role, FXR is a highly important liver protector and FXR inhibition by antagonists or knockout has shown several deleterious effects. A recent report characterized non-steroidal anti-rheumatic drugs (NSAIDs) such as ibuprofen or diclofenac as FXR antagonists and linked hepatotoxic effects of these drugs with antagonistic activity on FXR. Since this would guide a wa ...[more]
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