Ontology highlight
ABSTRACT:
SUBMITTER: Vu MM
PROVIDER: S-EPMC4591938 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Vu Michael M K MM Jameson Nora E NE Masuda Stuart J SJ Lin Dana D Larralde-Ridaura Rosa R Lupták Andrej A
Chemistry & biology 20121001 10
Aptamers are structured macromolecules in vitro evolved to bind molecular targets, whereas in nature they form the ligand-binding domains of riboswitches. Adenosine aptamers of a single structural family were isolated several times from random pools, but they have not been identified in genomic sequences. We used two unbiased methods, structure-based bioinformatics and human genome-based in vitro selection, to identify aptamers that form the same adenosine-binding structure in a bacterium, and s ...[more]