Ontology highlight
ABSTRACT:
SUBMITTER: Bekker P
PROVIDER: S-EPMC4592714 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Bekker Pirow P Ebsworth Karen K Walters Matthew J MJ Berahovich Robert D RD Ertl Linda S LS Charvat Trevor T TT Punna Sreenivas S Powers Jay P JP Campbell James J JJ Sullivan Timothy J TJ Jaen Juan C JC Schall Thomas J TJ
Mediators of inflammation 20150920
While it has long been established that the chemokine receptor CCR9 and its ligand CCL25 are essential for the movement of leukocytes into the small intestine and the development of small-intestinal inflammation, the role of this chemokine-receptor pair in colonic inflammation is not clear. Toward this end, we compared colonic CCL25 protein levels in healthy individuals to those in patients with ulcerative colitis. In addition, we determined the effect of CCR9 pharmacological inhibition in the m ...[more]