Ontology highlight
ABSTRACT:
SUBMITTER: Strong BS
PROVIDER: S-EPMC4592829 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Strong Beverly S I BS Ryken Katherine O KO Lee Amanda E AE Turner Lucas E LE Wadhwani Ram K RK Newkold Tess J TJ Alhajjat Amir M AM Heusel Jonathan W JW Shaaban Aimen F AF
Journal of immunology (Baltimore, Md. : 1950) 20150911 8
Transplanting stem cells before birth offers an unparalleled opportunity to initiate corrective treatment for numerous childhood diseases with minimal or no host conditioning. Although long-term engraftment has been demonstrated following in utero hematopoietic cellular transplantation during immune quiescence, it is unclear if prenatal tolerance becomes unstable with immune activation such as during a viral syndrome. Using a murine model of in utero hematopoietic cellular transplantation, the i ...[more]