Ontology highlight
ABSTRACT:
SUBMITTER: Li R
PROVIDER: S-EPMC4592832 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Li Rongpeng R Tan Shirui S Yu Min M Jundt Michael C MC Zhang Shuang S Wu Min M
Journal of immunology (Baltimore, Md. : 1950) 20150914 8
Earlier studies reported that a cell membrane protein, Annexin A2 (AnxA2), plays multiple roles in the development, invasion, and metastasis of cancer. Recent studies demonstrated that AnxA2 also functions in immunity against infection, but the underlying mechanism remains largely elusive. Using a mouse infection model, we reveal a crucial role for AnxA2 in host defense against Pseudomonas aeruginosa, as anxa2(-/-) mice manifested severe lung injury, systemic dissemination, and increased mortali ...[more]