Withaferin A Analogs That Target the AAA+ Chaperone p97.
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ABSTRACT:
SUBMITTER: Tao S
PROVIDER: S-EPMC4593394 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Withaferin A Analogs That Target the AAA+ Chaperone p97.
Tao Shasha S Tillotson Joseph J Wijeratne E M Kithsiri EMK Xu Ya-Ming YM Kang MinJin M Wu Tongde T Lau Eric C EC Mesa Celestina C Mason Damian J DJ Brown Robert V RV Clair James J La JJ Gunatilaka A A Leslie AAL Zhang Donna D DD Chapman Eli E
ACS chemical biology 20150603 8
Understanding the mode of action (MOA) of many natural products can be puzzling with mechanistic clues that seem to lack a common thread. One such puzzle lies in the evaluation of the antitumor properties of the natural product withaferin A (WFA). A variety of seemingly unrelated pathways have been identified to explain its activity, suggesting a lack of selectivity. We now show that WFA acts as an inhibitor of the chaperone, p97, both in vitro and in cell models in addition to inhibiting the pr ...[more]
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