Ontology highlight
ABSTRACT:
SUBMITTER: Gabbita SP
PROVIDER: S-EPMC4593589 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Gabbita S Prasad SP Johnson Ming F MF Kobritz Naomi N Eslami Pirooz P Poteshkina Aleksandra A Varadarajan Sridhar S Turman John J Zemlan Frank F Harris-White Marni E ME
PloS one 20151005 10
Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought to impair phagocytosis and has been described in Alzheimer's Disease (AD). Neuroinflammation can be perpetuated by a cycle of increasing cytokine production and maintenance of a polarized activation state that contributes to AD progression. In this study, 3xTgAD mice, age 6 months, were treated orally with 3 doses of the TNFα modulating c ...[more]