Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC2988870 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Liu Dong D Pitta Michael M Lee Jong-Hwan JH Ray Balmiki B Lahiri Debomoy K DK Furukawa Katsutoshi K Mughal Mohamed M Jiang Haiyang H Villarreal Julissa J Cutler Roy G RG Greig Nigel H NH Mattson Mark P MP
Journal of Alzheimer's disease : JAD 20100101 2
Compromised cellular energy metabolism, cerebral hypoperfusion, and neuronal calcium dysregulation are involved in the pathological process of Alzheimer's disease (AD). ATP-sensitive potassium (KATP) channels in plasma membrane and inner mitochondrial membrane play important roles in modulating neuronal excitability, cell survival, and cerebral vascular tone. To investigate the therapeutic potential of drugs that activate KATP channels in AD, we first characterized the effects of the KATP channe ...[more]