Ontology highlight
ABSTRACT:
SUBMITTER: Samai P
PROVIDER: S-EPMC4594840 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Samai Poulami P Pyenson Nora N Jiang Wenyan W Goldberg Gregory W GW Hatoum-Aslan Asma A Marraffini Luciano A LA
Cell 20150507 5
Immune systems must recognize and destroy different pathogens that threaten the host. CRISPR-Cas immune systems protect prokaryotes from viral and plasmid infection utilizing small CRISPR RNAs that are complementary to the invader's genome and specify the targets of RNA-guided Cas nucleases. Type III CRISPR-Cas immunity requires target transcription, and whereas genetic studies demonstrated DNA targeting, in vitro data have shown crRNA-guided RNA cleavage. The molecular mechanism behind these di ...[more]