Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis.
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ABSTRACT:
SUBMITTER: Li-ChunHsieh K
PROVIDER: S-EPMC4595933 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis.
Li-ChunHsieh Kevin K Schob Stefan S Zeller Matthias W G MW Pulli Benjamin B Ali Muhammad M Wang Cuihua C Chiou Terry Ting-Yu TT Tsang Yuk-Ming YM Lee Po-Shun PS Stossel Thomas P TP Chen John W JW
Journal of neuroimmunology 20150809
Gelsolin is the fourth most abundant protein in the body and its depletion in the blood has been found in multiple sclerosis (MS) patients. How gelsolin affects the MS brain has not been studied. We found that while the secreted form of gelsolin (pGSN) decreased in the blood of experimental autoimmune encephalomyelitis (EAE) mice, pGSN concentration increased in the EAE brain. Recombinant human pGSN (rhp-GSN) decreased extracellular actin and myeloperoxidase activity in the brain, resulting in r ...[more]
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