Ontology highlight
ABSTRACT:
SUBMITTER: Jameson VJ
PROVIDER: S-EPMC4596152 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Jameson Victoria J A VJ Cochemé Helena M HM Logan Angela A Hanton Lyall R LR Smith Robin A J RA Murphy Michael P MP
Tetrahedron 20151101 44
A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo. ...[more]