Ontology highlight
ABSTRACT:
SUBMITTER: Han X
PROVIDER: S-EPMC7032231 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Han Xue X Su Ruijuan R Huang Xiuqing X Wang Yingli Y Kuang Xiao X Zhou Shuang S Liu Hongzhuo H
Asian journal of pharmaceutical sciences 20180918 5
Mitochondria are currently known as novel targets for treating cancer, especially for tumors displaying multidrug resistance (MDR). This present study aimed to develop a mitochondria-targeted delivery system by using triphenylphosphonium cation (TPP<sup>+</sup>)-conjugated Brij 98 as the functional stabilizer to modify paclitaxel (PTX) nanocrystals (NCs) against drug-resistant cancer cells. Evaluations were performed on 2D monolayer and 3D multicellular spheroids (MCs) of MCF-7 cells and MCF-7/A ...[more]