Ontology highlight
ABSTRACT:
SUBMITTER: Murphy KE
PROVIDER: S-EPMC4596484 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Pharmacogenetics and genomics 20151101 11
A polymorphism in the receptor for the Fc region of IgG, Fc γ-receptor IIIa (FcγRIIIa, FCGR3A rs396991), has been inconsistently shown in the literature to have an effect on response to monoclonal antibody therapy in several indications. The rs396991 (T/G) polymorphism leads to an F176V substitution and increased affinity for IgG. This variant has proven difficult to genotype accurately, primarily because of extensive homology between the FCGR3A and FCGR3B genes. We have shown that rs396991 can ...[more]