Dataset Information

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

ABSTRACT:

Rationale

Evidence suggests that the gut microbiome is involved in the development of cardiovascular disease, with the host-microbe interaction regulating immune and metabolic pathways. However, there was no firm evidence for associations between microbiota and metabolic risk factors for cardiovascular disease from large-scale studies in humans. In particular, there was no strong evidence for association between cardiovascular disease and aberrant blood lipid levels.

Objectives

To identify intestinal bacteria taxa, whose proportions correlate with body mass index and lipid levels, and to determine whether lipid variance can be explained by microbiota relative to age, sex, and host genetics.

Methods and results

We studied 893 subjects from the Life-Lines-DEEP population cohort. After correcting for age and sex, we identified 34 bacterial taxa associated with body mass index and blood lipids; most are novel associations. Cross-validation analysis revealed that microbiota explain 4.5% of the variance in body mass index, 6% in triglycerides, and 4% in high-density lipoproteins, independent of age, sex, and genetic risk factors. A novel risk model, including the gut microbiome explained ? 25.9% of high-density lipoprotein variance, significantly outperforming the risk model without microbiome. Strikingly, the microbiome had little effect on low-density lipoproteins or total cholesterol.

Conclusions

Our studies suggest that the gut microbiome may play an important role in the variation in body mass index and blood lipid levels, independent of age, sex, and host genetics. Our findings support the potential of therapies altering the gut microbiome to control body mass, triglycerides, and high-density lipoproteins.

SUBMITTER: Fu J

PROVIDER: S-EPMC4596485 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Publications

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

Fu Jingyuan J Bonder Marc Jan MJ Cenit María Carmen MC Tigchelaar Ettje F EF Maatman Astrid A Dekens Jackie A M JA Brandsma Eelke E Marczynska Joanna J Imhann Floris F Weersma Rinse K RK Franke Lude L Poon Tiffany W TW Xavier Ramnik J RJ Gevers Dirk D Hofker Marten H MH Wijmenga Cisca C Zhernakova Alexandra A

Circulation research 20150910 9

<h4>Rationale</h4>Evidence suggests that the gut microbiome is involved in the development of cardiovascular disease, with the host-microbe interaction regulating immune and metabolic pathways. However, there was no firm evidence for associations between microbiota and metabolic risk factors for cardiovascular disease from large-scale studies in humans. In particular, there was no strong evidence for association between cardiovascular disease and aberrant blood lipid levels.<h4>Objectives</h4>To ...[more]

PMID: 26358192

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Dataset Information

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

Rationale

Objectives

Methods and results

Conclusions

Publications

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

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