The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

ABSTRACT:

Rationale

Evidence suggests that the gut microbiome is involved in the development of cardiovascular disease, with the host-microbe interaction regulating immune and metabolic pathways. However, there was no firm evidence for associations between microbiota and metabolic risk factors for cardiovascular disease from large-scale studies in humans. In particular, there was no strong evidence for association between cardiovascular disease and aberrant blood lipid levels.

Objectives

To identify intestinal bacteria taxa, whose proportions correlate with body mass index and lipid levels, and to determine whether lipid variance can be explained by microbiota relative to age, sex, and host genetics.

Methods and results

We studied 893 subjects from the Life-Lines-DEEP populatio

SUBMITTER: Fu J 

PROVIDER: S-EPMC4596485 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature