Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC4596636 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Chen Lizhen L Chuang Marian M Koorman Thijs T Boxem Mike M Jin Yishi Y Chisholm Andrew D AD
eLife 20150904
Axon injury triggers a series of changes in the axonal cytoskeleton that are prerequisites for effective axon regeneration. In Caenorhabditis elegans the signaling protein Exchange Factor for ARF-6 (EFA-6) is a potent intrinsic inhibitor of axon regrowth. Here we show that axon injury triggers rapid EFA-6-dependent inhibition of axonal microtubule (MT) dynamics, concomitant with relocalization of EFA-6. EFA-6 relocalization and axon regrowth inhibition require a conserved 18-aa motif in its othe ...[more]