Ontology highlight
ABSTRACT:
SUBMITTER: Unckless RL
PROVIDER: S-EPMC4596658 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Genetics 20150730 2
The use of recombinant genetic technologies for population manipulation has mostly remained an abstract idea due to the lack of a suitable means to drive novel gene constructs to high frequency in populations. Recently Gantz and Bier showed that the use of CRISPR/Cas9 technology could provide an artificial drive mechanism, the so-called mutagenic chain reaction (MCR), which could lead to rapid fixation of even a deleterious introduced allele. We establish the near equivalence of this system to o ...[more]