Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus.
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ABSTRACT:
SUBMITTER: Monot M
PROVIDER: S-EPMC4597214 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus.
Monot Marc M Eckert Catherine C Lemire Astrid A Hamiot Audrey A Dubois Thomas T Tessier Carine C Dumoulard Bruno B Hamel Benjamin B Petit Amandine A Lalande Valérie V Ma Laurence L Bouchier Christiane C Barbut Frédéric F Dupuy Bruno B
Scientific reports 20151008
The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tcdE). To date, the PaLoc has always been found in the same location and is replaced in non-toxigenic strains by a highly conserved 75/115 bp non-coding region. Here, we show new types of C. difficile pathogenicity loci through t ...[more]
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