Ontology highlight
ABSTRACT:
SUBMITTER: Grasso F
PROVIDER: S-EPMC4598774 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Biomolecules 20150811 3
Bacterial genotoxins are unique among bacterial toxins as their molecular target is DNA. The consequence of intoxication or infection is induction of DNA breaks that, if not properly repaired, results in irreversible cell cycle arrest (senescence) or death of the target cells. At present, only three bacterial genotoxins have been identified. Two are protein toxins: the cytolethal distending toxin (CDT) family produced by a number of Gram-negative bacteria and the typhoid toxin produced by Salmon ...[more]