Ontology highlight
ABSTRACT:
SUBMITTER: Rawlinson SM
PROVIDER: S-EPMC6076271 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180803 1
Recent studies indicate that nucleoli play critical roles in the DNA-damage response (DDR) via interaction of DDR machinery including NBS1 with nucleolar Treacle protein, a key mediator of ribosomal RNA (rRNA) transcription and processing. Here, using proteomics, confocal and single molecule super-resolution imaging, and infection under biosafety level-4 containment, we show that this nucleolar DDR pathway is targeted by infectious pathogens. We find that the matrix proteins of Hendra virus and ...[more]