Ontology highlight
ABSTRACT:
SUBMITTER: Sun CS
PROVIDER: S-EPMC4598856 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20151009
The abundant accumulation of inclusion bodies containing polyglutamine-expanded mutant huntingtin (mHTT) aggregates is considered as the key pathological event in Huntington's disease (HD). Here, we demonstrate that FKBP12, an isomerase that exhibits reduced expression in HD, decreases the amyloidogenicity of mHTT, interrupts its oligomerization process, and structurally promotes the formation of amorphous deposits. By combining fluorescence-activated cell sorting with multiple biophysical techn ...[more]